Advantages:
- Waterless foams offer a superior topical
delivery system
- Useful in delivering water-sensitive drugs
- Full disolution of hydrophilic and lipophilic drugs (e.g., mupirocin,
acyclovir, insoluble corticosteroids).
- Excellent stability
- Well absorbed with no need of extensive rubbing
- No residual sticky feeling or shiny look
- High humectant effect, as expected from PG and glycerin
- Penetration enhancement
- An abstract detailing the development of this new technological platform entitled
“Innovative waterless hydrophilic topical foam”
presented at the 33rd Annual Meeting of the Controlled Release Society (CRS) in Vienna, Austria, July 22–26, 2006
PG - based waterless foam
- PG - based foams have been used to incorporate the following corticosteroid
drugs:
- Low potency
steroids
- Mid potency steroids
- Betamethasone valerate
- Hydrocortisone butyrate
- Fluocinolone acetonide
- High potency steroids
- Fluticasone propionate
- Betamethasone dipropionate
- Mometasone furoate
- Super high
potency steroids
Exemplary stability results are demonstrated in the following Table:
| Product |
T0 |
1 Month |
Degradation Products |
| 25ºC |
40ºC |
| Betamethasone valerate 0.12% |
0.117 |
0.108 |
0.110 |
Below limit of detection |
| Clobetasol propionate 0.05% |
0.052 |
0.051 |
0.049 |
| Betamethasone Dipropionate 0.05% |
0.047 |
0.049 |
0.047 |
| Fluocinolone Acetonide 0.025% |
0.024 |
0.024 |
0.024 |
| Hydrocortisone Butyrate 0.1% |
0.097 |
0.094 |
0.093 |
PG based foams were also used for non-steroid API’s such as Minoxidil and Acyclovir.
PEG-based waterless foam
PEG-based waterless foam is used as a vehicle for Mupirocin (Mupifoam™).
Partnering
Foamix has completed the development of several Waterless Foam™ products, currently available for marketing and/or advanced development.
Foamix is actively seeking development and marketing partners for its Waterless Foam™ platform products.
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